Cyclodepsipeptides and Other O-Containing Heterocyclic Metabolites from Beauveria felina EN-135, a Marine-Derived Entomopathogenic Fungus
نویسندگان
چکیده
Bioassay-guided fractionation of a culture extract of Beauveria felina EN-135, an entomopathogenic fungus isolated from a marine bryozoan, led to the isolation of a new cyclodepsipeptide, iso-isariin D (1); two new O-containing heterocyclic compounds that we have named felinones A and B (2 and 3); and four known cyclodepsipeptides (4-7). The structures were elucidated via spectroscopic analysis, and the absolute configurations of 1 and 2 were determined using single-crystal X-ray diffraction and CD, respectively. All isolated compounds were evaluated for antimicrobial activity and brine-shrimp (Artemia salina) lethality.
منابع مشابه
In Vitro and In Vivo Induction, and Characterization of Beauvericin Isolated from Beauveria bassiana and Its Bioassay on Galleria mellonella Larvae
Entomopathogenic fungi produce secondary metabolites which may bioactively help fungus in its virulence toward insect hosts. Beauveria bassiana produces several toxic low molecular compounds in vitro as well as in vivo, the most important of them is Beauvericin. The BEH isolate of the fungus was selected for Beauvericin assay. Beauvericin was obtained from surface and submerged cultures of the ...
متن کاملCyclodepsipeptides, sesquiterpenoids, and other cytotoxic metabolites from the filamentous fungus Trichothecium sp. (MSX 51320).
Two new cyclodepsipeptides (1 and 2), two new sesquiterpenoids (3 and 4), and the known compounds guangomide A (5), roseotoxin S, and three simple trichothecenes were isolated from the cytotoxic organic extract of a terrestrial filamentous fungus, Trichothecium sp. The structures were determined using NMR spectroscopy and mass spectrometry. Absolute configurations of the cyclodepsipeptides were...
متن کاملCellular Immune Reactions of the Sunn Pest, Eurygaster integriceps, to the Entomopathogenic Fungus, Beauveria bassiana and Its Secondary Metabolites
In this study, five morphological types of circulating hemocytes were recognized in the hemolymph of the adult sunn pest, Eurygaster integriceps Puton (Hemiptera: Scutelleridae), namely prohemocytes, plasmatocytes, granulocytes, adipohemocytes, and oenocytoids. The effects of the secondary metabolites of the entomopathogenic fungus Beauveria bassiana on cellular immune defenses of Eurygaster in...
متن کاملCompatibility of the entomopathogenic fungus Beauveria bassiana with the insecticides fipronil, pyriproxyfen and hexaflumuron
سازگاری سه حشره‌کش فیپرونیل، پایری‌پروکسی‌فن و هگزافلومورون با جدایه‌ی DEBI 002 (آتشگاه) قارچ Beauveria bassiana مورد بررسی قرار گرفت. برای تعیین اثر این حشره‌کشها روی جوانه‌زنی اسپور قارچ، غلظت‌های مختلف آن‌ها به محیط کشت مالت آگار اضافه شد. به‌منظور محاسبه‌ی میزان رشد میسیلیوم در تیمارهای مختلف، قطر کلنی اندازه‌گیری شد و ارزیابی میزان اسپورزایی با شمارش اسپورها در واحد سطح صورت گرفت. نتایج نش...
متن کاملESTABLISHMENT OF THE FUNGAL ENTOMOPATHOGEN Beauveria bassiana AS AN ENDOPHYTE IN COCOA PODS (Theobroma cacao L.) ESTABLECIMIENTO DEL HONGO ENTOMOPATÓGENO Beauveria bassiana COMO ENDÓFITO EN FRUTOS DE CACAO (Theobroma cacao L.)
The entomopathogenic fungus Beauveria bassiana was re-isolated from surface sterilized pieces of the cocoa pod outer section and peduncle, two and three months after flowers of greenhouse cocoa plants were hand-pollinated and sprayed with a 1x107 mL-1 suspension of B. bassiana conidia. The colonization frequency of B. bassiana on cocoa pods was 0.8% and 1.3% two and three months post-spraying o...
متن کامل